PDF | Libidibia ferrea, popularly known as “pau ferro” or “jucá”, is an important medicinal plant employed for the treatment of various ailments in. Genus: Libidibia (formerly known as Ceasalpinia). species: ferrea. Family: Fabaceae. Common Name: Leopard tree, Brazilian Ironwood. Description. Unarmed tree, to 15 m. Bark very distinctive, smooth, grey, pealing to reveal paler patches. Leaves 2-pinnate; pinnae in pairs, each with

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BioMed Research International

Histochemical tests in the longitudinal section of seeds of Libidibia ferrea. Tumor inhibition was expressed as the mean of tumor weight for the treated animal group T in comparison to the untreated control group C. Natural products, known as secondary metabolites of plants or animals, continue to be an important segment of research into new drugs. After one hour, 0. This method is simple and reliable and affords rapid evaluation of peripheral analgesic action [ 42 ].

Modulating leukocyte recruitment in inflammation. Further pharmacological and chemical studies are necessary to confirm and to better characterize the exact mechanism s responsible for the antinociceptive action.

Libidibia ferrea – Wikipedia

The effects of different antagonists on the antinociceptive activity of the LPLF in the acetic acid-induced contortions. This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

So, the search for drugs that act upon cell migration may be of great interest. Materials and Methods 2.

The negative control group was given saline, always in the same route of administration as the drug. Libidibiaa authors are also grateful for the technical assistance of Mrs. Illustrated Cyclopedia of Brazilian Medicinal Plants.


It penetrates easily into damaged cells staining them blue, while the intact ones remain colorless, allowing determination of living and dead cell percentages. Phytolaccaceae Journal of Pharmacy and Bioallied Sciences. To receive news and publication updates for BioMed Research International, enter your email address in the box below.

Libidibia ferrea

Antitumor Activity F80 showed a tumor growth inhibition of 8. He has a keen interest in science, the natural world and particularly our environment. In summary, Libidibia ferrea has a large amount of lipids storage sites in different seed parts containing different lipids unsaturated, neutral, and acid. Pau ferro, used as a rosewood substitute, is a strong sensitizer capable of causing acute outbreaks of allergic and irritant dermatitis in workers not previously exposed to it.

Asterisks denote the significance level in comparison to the control ,ibidibia As shown in Table 2 and Figure 4both preparations protected mice against chemically induced noxious stimulus, causing an inhibition at the rate of European Journal of Pharmacology.

After collecting the material, seeds of Libidibia ferrea were libiribia for extraction. Articles with ‘species’ microformats. Retrieved 23 June Histochemical tests and Gas chromatography of the LPLF were performed to characterize its fatty acids. Reversal of the antinociceptive effect by opioid antagonist indicates a participation in central forms of antinociception.

After these analyses, LPLF was used in subsequent antinociceptive tests hot-plate and formalin-induced lickingwhich demonstrated a significant analgesic effect in both tests, confirming that the antinociceptive libieibia in the seeds extract could be attributed to at least one of LPLF components.

Histochemical seed analyses showed a mesotest composition and storage of endosperm between the exotest and cotyledon Figures 2 b and 2 cwhich is commonly the main seed storage tissues in the endospermic llbidibia, although LF presented a complete absorption of the endosperm during ferreq embryogenesis libidiba 715 ].


CE and F80 promoted a high reduction in the content of nitrite, especially CE, which decreased it to a level smaller than those presented by the standard drugs, as shown in Figure 3. Propagation from older wood cuttings and libdiibia into a plant hormone. The control groups received the same volume, 0. LPLF could cause pain inhibition mainly by two neuronal pain mechanisms: Table 2 Antinociceptive effect of standard drugs piroxicam and dipyroneCE, and F80 on acetic acid-induced ferrez response test in mice.

Due to a significant layer of oil present in the seed extract used in the experiments, it was pondered if the analgesic agent s were present in this lipophilic portion. Pathways of reduced pyridine nucleotide oxidation in rat-brain homogenate demonstrated by a tetrazolium method.

Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages. Maria Barbosa Reis da Silva and Mr. Biochimica et Biophysica Acta.

Several previous studies have demonstrated that plant extracts and derivative oibidibia have an anticancer potential in vitro or in vivo. They will drop leaves all-year round with increases in autumn.

Additionally, findings in Nile blue sulphate test possibly confirm the presence of the triacylglycerols in the oily bodies Figures 2 g and 2 h. There are different routes to evaluate nociception; however, the assay using intraperitoneally acetic fwrrea was the chosen approach. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules.